- Duración
- 01/05/2017-30/04/2022
- Coordinador
- Clara Menéndez
- Financiadores
- UNITAID
- Página web
- https://www.tiptopmalaria.org
In sub-Saharan Africa (SSA), over 30 million pregnant women are annually exposed to infection from malaria. Of these, an estimated 10,000 pregnant women and up to 200,000 newborns die from malaria in pregnancy (MiP), primarily due to the infection from Plasmodium falciparum bites. Furthermore, recent data indicate that up to 20% of stillbirths in SSA are attributable to MiP. In the broader framework of the 2030 agenda, the TIPTOP project is well aligned with the overall SDG3 health targets of accelerating maternal and newborn mortality reduction in the Sub Saharan region and reflects well how different stakeholders have a role and responsibility in helping to achieve these ambitious goals: from sub Saharan African countries to donors, international development and research partners.
IThis 5-year project, funded by UNITAID and implemented by Jhpiego (coordinator) and ISGlobal (research partner) in collaboration with the World Health Organization (WHO) and the Medicines for Malaria Venture (MMV), aims to increase intermittent preventive treatment in pregnancy (IPTp) for malaria with sulfadoxine-pyrimethamine (SP)—in addition to the use of insecticide-treated bed nets (ITNs) and effective case management IPTp coverage— and expand antenatal care attendance primarily through Community Health Workers in four Sub Saharan African countries: DRC, Mozambique, Madagascar and Nigeria. A learning-driven approach will be employed throughout the project to guide expansion in a two-phase process and generate sufficient evidence to inform WHO policy recommendations and future actions in each country, in an effort to expand the intervention over the long-term.
In an initial phase 10,000 pregnant women per country are expected to be reached (2 years). Then in the so-called expansion phase (3 years) 30,000 pregnant women per country will be enrolled. This project plans to engage community health workers to increase IPTp delivery and demand, catalyzing and further encouraging scale-up of IPTp in Africa. Additionally, it will expand antenatal care attendance in these four African countries.
ISGlobal is the lead evaluation and research organization and is responsible for implementing a set of studies to generate evidence for global guidance on community IPTp-SP. Specifically, ISGlobal will be responsible for designing and implementing the project’s evaluation plan, as well as designing, analyzing and reporting the operational research studies to assess the cost and acceptability of the intervention and its impact.
Total funding:
- Total Project Funding: $50M
- Total ISGlobal Funding: $10.4 M
More Information:
- Landmark Agreement Signed to Prevent Malaria in Pregnancy (ISGlobal)
- Landmark agreement signed to prevent malaria in pregnancy and reduce life-threatening complications in sub-Saharan Africa (UNITAID)
- Malaria in Pregnancy: Intermittent Preventive Treatment (ISGlobal)
Nuestro equipo
PI
-
Clara Menéndez Santos
ISGlobal team
-
Franco Massimo Giovanni Pagnoni Coordinador de Cooperación Técnica
-
Mireia Llach Medical Research Fellow
-
Maria del Pilar Fontserè Serra
-
Susana Méndez Bartolomé
-
MONTSE PI Project Assistant
-
Maximo Ramirez Robles
Otros proyectos
Ver proyectos pasadosICARIA
Improving Care through Azithromycin Research for Infants in Africa
NHEPACHA
Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas
Estudio inmunológico de la vacuna RTS,S
Estudio de correlatos de protección frente a la malaria después de la vacunación con RTS,S/AS01E: Una evaluación inmunológica exhaustiva en el ensayo clínico de Fase III, doble ciego, aleatorizado, multicéntrico con un grupo control
Euroleish.net
Control of Leishmaniasis. From bench to bedside and community
GREPIMER
Grup de recerca en patología importada i malaties emergents i re-emergents
TESEO
Nuevos regímenes de quimioterapia y biomarcadores para la enfermedad de Chagas
ASINTMAL
Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults
ADAM
Administración masiva y focal de fármacos antimaláricos para avanzar hacia la eliminación de la malaria en Mozambique: acelerando la implementación de programas y políticas
MULTIPLY
MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention
Science4Pandemics
Citizens engagement digital platform for collective intelligence in pandemics
HIDDENVIVAX
Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria
Subclinical Infections in Children and Long Term Health Effects
Infection acquisition in early life and health outcomes in childhood - MARATO TV3
Herramienta innovadora de detección de enfermedades y vacunación a población inmigrante en riesgo en España
Project Code: PI21/00651
Impacto de las coinfecciones en el balance de respuestas de anticuerpos y linfocitos T helper a antígenos diana de inmunidad natural y vacunal frente a patógenos humanos prominentes
Project Code: PI20/00866
EpiGen
Building Scalable Pathogen Genomic Epidemiology in Ethiopia
MalTransc
Transcriptional regulation of adaptation and developmental decisions in malaria parasites: from epigenetic variation to directed transcriptional responses
BOHEMIA
Broad One Health Endectocide-based Malaria Intervention in Africa
RESPONSE
Mechanisms of the transcriptional responses to changes in the environment in the malaria parasite Plasmodium falciparum
VivaxEVTalk
Extracellular Vesicles as Intercellular Communicators and Biomarkers of Cryptic Erythrocytic Infections in Plasmodium vivax malaria
VaMonoS
Unravelling the heterogoneity and function of monocytes in vaccination and immunity to malaria
CLIMSOCTRYPBOL
Insight on climate and social participatory research for integral management of vectorborne zoonosis caused by Trypanosoma cruzi and Leishmania spp. in the Bolivian Gran Chaco.
SexMal
Social affairs and sex in P. falciparum: implications for malaria elimination
MENA Migrant Health
Transforming data collection and surveillance to drive migrant health research, care and policy
MESA
La Alianza Científica para la Erradicación de la Malaria (MESA) tiene como objetivo avanzar en la ciencia de la erradicación de la malaria.
GenMoz
P. falciparum genomic intelligence in Mozambique
SMART
Identifying Severe Malaria with a new Aptamer-based Rapid diagnostic Test
CaDMIA-plus
Validación continuada de la autopsia mínimamente invasiva (MIA) para la investigación de la causa de muerte en niños pequeños, y desarrollo de un centro de investigación y formación sobre el estudio de la causa de muerte
MAMAH
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women
MIBio
Identification of Prematurity and Pre-Eclampsia as Causes of Mortality
MA-CoV
Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations
IPERVAC-SL
Impact of perceptions of COVID-19 vaccines on health-seeking behaviours in Sierra Leone
RESPIRE
Respiratory syncytial virus (RSV) in African pregnant women and children
VITAL
Towards preparedness for new maternal vaccinations: Understanding barriers and facilitators to maternal vaccine acceptance
SARA (SARS-CoV-2 and Acetylsalicylic acid)
Efficacy of low dose acetylsalicylic acid in preventing adverse maternal and perinatal outcomes in SARS-CoV-2 infected pregnant women
HIV drug resistance (HIVDR)
Description of HIV drug resistance patterns and its association with the risk of HIV mother to child transmission among pregnant women from southern Mozambique
Evaluación de la eficacia del ácido acetilsalicílico a dosis bajas en la prevención de los efectos maternos y perinatales adversos en mujeres embarazadas infectadas por el SARS-CoV-2
PROTECT
PReparing for Optimal Phase III/IV maTErnal Group B StreptococCal vaccine Trials in Africa