Investigación, Chagas

ChagasLAMP (GHIT G2020-203)

Field validation of Trypanosoma cruzi-LAMP: a molecular point-of-care test for the control of congenital Chagas disease

Foto: Ana Ferreira

Duración: 01/04/2021 - 31/03/2023
Coordinador: Julio Alonso
Financiadores: Global Health Innovative Fund (GHIT)

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects ~7 million people, mostly in Latin America. Vector-borne transmission is on the way of being controlled in several countries, but vertical transmission remains an uncontrolled major public-health challenge. Remarkably, available drugs have a very high cure rate in T. cruzi-infected newborns if administered early upon infection, thus a timely diagnose is crucial for treatment success.

However, the algorithm to detect congenital T. cruzi infection involves parasitological methods that lack sensitivity and a serological study must be performed several months later. In many endemic regions, people live far from referral centres which entails that a large proportion of infants rarely go back for diagnosis confirmation and treatment, if infected. Consequently, they evolve to the chronic phase of the disease with the risk of developing severe manifestations.

Molecular-based diagnostics have a very high sensitivity to detect congenital T. cruzi infections, but laboratories in those distant regions are not equipped to perform them. With the aim to provide a suitable point-of-care (POC) test for the timely diagnosis of congenital Chagas disease in these settings, we will validate the implementation of EIKEN T. cruzi loop-mediated isothermal amplification (LAMP) prototype in the field.

Total Funding

¥ 147,127,368

Coordinator

Julio Alonso Padilla Assistant Research Professor, Director of the Chagas Initiative

ISGlobal Team

Aina Casellas Torrentó
Laura Ferradino Research Assistant
Quim Gascon Research Professor, Director of the Chagas Initiative
Susana Méndez Bartolomé
Mirko Rojas Consultor y coordinador de campo en Bolivia
SERGI SANZ Responsable de Departamento - Estadística
Arantxa Sarrà Barrés
MONICA SOLANES Asesor de Cartera

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ISGlobal Team

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