Asset Publisher

Research & Innovation Programmes
Research

LIFECYCLE

Early-life stressors and LifeCycle health

Duration
2017-2021
Coordinator
Vincent Jaddoe (Erasmus MC-University Medical Center de Rotterdam)
Funded by
European Comission - Horizon 2020
Website
http://www.lifecycle-project.eu

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer a unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of noncommunicable diseases.

LifeCycle will establish the EU CHILD Cohort Network, which brings together existing, successful pregnancy and child cohorts and biobanks, by developing a governance structure taking account of national and European ethical, legal and societal implications, a shared data-management platform and data-harmonization strategies.

The project will enrich this EU CHILD Cohort Network by generating new integrated data on early life stressors related to socio-economic, migration, urban environment and life-style determinants, and will capitalize on these data by performing hypothesis-driven research on early life stressors influencing cardio-metabolic, respiratory and mental health trajectories during the full lifecycle, and the underlying epigenetic mechanisms. LifeCycle  will translate these results into recommendations for targeted strategies and personalized prediction models to improve health trajectories for current and future Europeans generations by optimizing their earliest phase of life.

To strengthen this long-term collaboration, LifeCycle will organize yearly international meetings open to pregnancy and child cohort researchers, introduce a Fellowship Training Programme for exchange of junior researchers between European pregnancy or child cohorts, and develop e-learning modules for researchers performing life-course health studies.

Ultimately, the project will lead to a unique sustainable EU CHILD Cohort Network, and provide recommendations for targeted prevention strategies by identification of novel markers of early life stressors related to health trajectories throughout the lifecycle.

This ambitious project combines data on over 250,000 children and their parents from Europe and Australia to provide robust scientific evidence on this important topic. Research findings will be translated into new prevention and intervention policies focused on the earliest phase of life, giving next generations the best possible start.

Partners

  • Erasmus Universitair Medisch Centrum Rotterdam, The Netherlands (Coordinator)
  • ISGlobal, Barcelona, Spain
  • University of Turin, Italy
  • University of Southampton, United Kingdom
  • University of Bristol, United Kingdom
  • University of Copenhagen, Denmark
  • Bradford Teaching Hospitals NHS Foundation Trust, United Kingdom
  • University Medical Center Groningen, The Netherlands
  • University of Crete, Greece
  • Norwegian Institute of Public Health, Oslo, Norway
  • French National Institute of Health and Medical Research (INSERM), Villejuif, France
  • University of Oulu, Finland
  • Samfundet Folkhälsan, Helsinki, Finland
  • Ludwig Maximilians University of Munich, Germany
  • VU University Amsterdam , The Netherlands
  • Concentris Research Management GmbH
  • University of Western Australia, Perth, Australia

 

Total funding

10,4 milions.

Our Team

Principal Investigators (PI)

ISGlobal Team

See More

Other projects

See Past Projects

MCC-Spain

Population based multicasecontrol study on common tumours in Spain

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohort of COVID-19 in Spain: social dynamics, mental health and inequalities

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health

IHEN

International Human Exposome Network

B-Triage

Una prueba en el punto de atención para la estratificación del riesgo de los pacientes febriles basada en los niveles de sTREM-1

e-QuoL

e-health tools to promote Equality in Quality of Life for childhood to young adulthood cancer patients, survivors and their families

AM-MENTAL

What happens with your mental health when your supervisor is an algorithm?