Publicador de contenidos

Investigación e Innovación Programas
Investigación

ALTER - Contaminación del aire, microbiota intestinal y neurodesarrollo en los primeros 24 meses de vida

Project Code: PI21/01278

Proyecto ALTER
Foto: Micael Widell / Pexels
Duración
01/01/2022 - 31/12/2024
Coordinador
Mireia Gascon
Financiadores
Instituto de Salud Carlos III. Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

The biological mechanisms by which early exposure to air pollution is associated with children's health effects, specifically neurodevelopment, is a significant knowledge gap, and more research is needed. Our hypothesis is that exposure to air pollution during pre- and postnatal life induces gut microbiota dysbiosis (i.e. alterations in gut microbiota composition and biological activity), which partially explains the association between air pollution exposure and subclinical neurodevelopment delays in the first years of life.

Objective

The main objective of the ALTER project is to longitudinally assess the impact that pre and post-natal exposure to air pollution has on the gut microbiota composition and its biological activity in the first two years of life.

We also aim to explore whether gut microbiota dysbiosis mediates the association between air pollution exposure and neurodevelopment outcomes.

The study will be conducted in a general population birth cohort (n=600) with a detailed assessment of prenatal and postnatal air pollution at personal and home levels. Gut microbiota composition (shot-gun metagenomics) and its biological activity (with the assessment of short chain fatty acids - SCFAs) will be assessed at the age of 6 and 18 months, while neurodevelopment will be assessed between the 6th and 24th month of life (using international validated tests).

Assessing the impact of air pollutants on subclinical events (i.e. gut microbiota alterations) is innovative and will allow advancing knowledge on the potential mechanisms by which air pollution affects neurodevelopment in early life.

Total Funding

122.000 €

Nuestro equipo

Project Coordinator

Otros proyectos

Ver proyectos pasados

MCC-Spain

Estudio multi-caso control poblacional, incluyendo tumores de alta incidencia en España

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohorte de COVID-19 en España: dinámica social, salud mental y desigualdades

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health

IHEN

International Human Exposome Network

B-Triage

Una prueba en el punto de atención para la estratificación del riesgo de los pacientes febriles basada en los niveles de sTREM-1

e-QuoL

e-health tools to promote Equality in Quality of Life for childhood to young adulthood cancer patients, survivors and their families

AM-MENTAL

¿Cómo afecta a tu salud mental que tu jefe o jefa sea un algoritmo?