Research, Chagas

Estudio de los procesos de inmunotrombosis y lipotoxicidad como mecanismos de patogénesis en la enfermedad de Chagas

Project Code: PI18/01054

Duration: 01/01/2019 - 30/06/2023
Coordinator: Joaquim Gascón
Funded by: Instituto de Salud Carlos III Unión Europea Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

La enfermedad de Chagas, causada por el parásito Trypanosoma cruzi, afecta a ~7 millones de personas, 65.000 de ellas en España.

Su principal manifestación clínica es el daño cardiaco y sólo hay dos fármacos disponibles para tratarla: benznidazol y nifurtimox. Ambos conceden una eficacia variable a costa de una elevada toxicidad, por lo que urge descubrir terapias mejores. No obstante, el desconocimiento de la patofisiología de la enfermedad obstaculiza este proceso.

El objetivo del presente proyecto es desenmascarar dichos mecanismos partiendo de dos líneas previas: (i) la infección crónica por T. cruzi ocasiona alteraciones a nivel hemostático que inducen un estado protrombótico; y (ii) la fase parasitaria que replica en mamíferos, los amastigotes, depende del metabolismo de ácidos grasos.

En relación, nuestras hipótesis son que:

La presencia sistémica intermitente del parásito da lugar a procesos de inmunotrombosis desregulada que son un factor de riesgo vascular
La presencia sistémica intermitente del parásito da lugar a procesos de inmunotrombosis desregulada que son un factor de riesgo vascular

Para identificar los mecanismos de patogénesis de T. cruzi realizaremos análisis metabolómicos de muestras de pacientes infectados e individuos sanos, y estudiaremos las interacciones del parásito con los distintos componentes de la sangre, así como con células endoteliales y cardiomiocitos humanos.

Financiación:

87.000 €

Coordinador

Quim Gascon Research Professor

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