Research

Impacto de las coinfecciones en el balance de respuestas de anticuerpos y linfocitos T helper a antígenos diana de inmunidad natural y vacunal frente a patógenos humanos prominentes

Project Code: PI20/00866

Duration: 01/01/2021 - 31/12/2023
Coordinator: Carlota Dobaño
Funded by: Instituto de Salud Carlos III Unión Europea Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

El objetivo es caracterizar el perfil inmune en individuos que viven áreas endémicas de VIH y malaria en África, y expuestos a enfermedades parasitarias desatendidas (helmintos y protozoos intestinales y esquistosoma) para comprender el impacto que la coexistencia de infecciones puede tener en el fenómeno de la desviación inmune y en respuesta a las vacunas.

Se harán analisis inmunológicos retrospectivos en muestras de sangre y heces ya recolectadas en estudios EcoHeMa y MARS cuyo objetivo era:

Evaluar la frecuencia de las coinfecciones por parásitos intestinales y malaria en pacientes ambulatorios y el impacto en la respuesta inmune y el microbioma intestinal (EcoHeMa).
Establecer la prevalencia de infección por parásitos intestinales y esquistosoma a nivel comunitario en el distrito de Manhiça (MARS).

Nuestro objetivo ahora es caracterizar el patrón de coinfecciones por diferentes especies de parásitos sanguíneos e intestinales (helmintos y protozoos), con o sin coinfección con VIH, y evaluar el patrón de respuestas inmunes innatas, humorales y celulares (citocinas Th1 , Th2, Th17, Treg) en coinfecciones por helmintos y malaria. La caracterización inmunológica medirá las respuestas de anticuerpos IgG e IgE a los antígenos de helmintos, que actualmente se están evaluando como posibles candidatos a vacunas en el Baylor College of Medicine (EE. UU.). Esta información será útil para guiar la selección de antígenos de vacunas candidatas contra helmintos.

Financiación total:

142.000€

Coordinador

Carlota Dobaño Research Professor

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