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Chagas

TcONTROL

Antigen-specific immunological biomarkers associated to control of infection by T. cruzi.

Duration: 01/01/2017-31/15/2019
Coordinator: Manuel Carlos López (IPBLN)
Funded by: MINECO

Los objetivos principales son:

Determinar en pacientes crónicos de Chagas el impacto del tratamiento con benznidazol en el perfil inmunológico (fenotípico y funcional) de las poblaciones linfocitarias T. El estudio se centrará en aquellos marcadores que se encuentren modificados según el grado de severidad de la patología de Chagas.
Caracterizar en un modelo de infección natural las modificaciones inducidas por el embarazo en el perfil inmunológico de linfocitos T CD4+ y CD8+, a nivel funcional y de expresión de receptores inhibitorios.
Analizar, utilizando un modelo murino de infección experimental, la respuesta inmunológica de células T (CD4 y CD8) potencialmente asociada al control de la infección por T. cruzi.

Financiación total:

121.000 €

ISGlobal team

Joaquim Gascon Brustenga
Maria Jesús Pinazo Delgado

Other projects

See Past Projects

NHEPACHA

New Tools for the Diagnosis and Evaluation of Chagas Disease

RTS,S Vaccine Immunology Study

Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial

Euroleish.net

Control of Leishmaniasis. From bench to bedside and community

GREPIMER

Grup de recerca en patología importada i malaties emergents i re-emergents

TESEO

New chemotherapy regimens and biomarkers for Chagas Disease

ASINTMAL

Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults

ADAM

Malaria mass and focal drug administration to advance malaria elimination in Mozambique: accelerating programmatic implementation and policy translation

MULTIPLY

MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention

Science4Pandemics

Citizens engagement digital platform for collective intelligence in pandemics

HIDDENVIVAX

Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria

Subclinical Infections in Children and Long Term Health Effects

Infection acquisition in early life and health outcomes in childhood - MARATO TV3

Herramienta innovadora de detección de enfermedades y vacunación a población inmigrante en riesgo en España

Project Code: PI21/00651

Impacto de las coinfecciones en el balance de respuestas de anticuerpos y linfocitos T helper a antígenos diana de inmunidad natural y vacunal frente a patógenos humanos prominentes

Project Code: PI20/00866

EpiGen

Building Scalable Pathogen Genomic Epidemiology in Ethiopia

MalTransc

Transcriptional regulation of adaptation and developmental decisions in malaria parasites: from epigenetic variation to directed transcriptional responses

BOHEMIA

Broad One Health Endectocide-based Malaria Intervention in Africa

RESPONSE

Mechanisms of the transcriptional responses to changes in the environment in the malaria parasite Plasmodium falciparum

VivaxEVTalk

Extracellular Vesicles as Intercellular Communicators and Biomarkers of Cryptic Erythrocytic Infections in Plasmodium vivax malaria

VaMonoS

Unravelling the heterogoneity and function of monocytes in vaccination and immunity to malaria

CLIMSOCTRYPBOL

Insight on climate and social participatory research for integral management of vectorborne zoonosis caused by Trypanosoma cruzi and Leishmania spp. in the Bolivian Gran Chaco.

SexMal

Social affairs and sex in P. falciparum: implications for malaria elimination

MENA Migrant Health

Transforming data collection and surveillance to drive migrant health research, care and policy

MESA

Sharing knowledge and catalyzing research towards a malaria-free world

GenMoz

P. falciparum genomic intelligence in Mozambique

SMART

Identifying Severe Malaria with a new Aptamer-based Rapid diagnostic Test

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Financiación total:

Our Team

ISGlobal team

Other projects

Cookies and privacy

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