Asset Publisher

Urban Planning, Environment and Health

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

FINDOOR project
Photo: Canva
Duration
01/09/2022 - 31/08/2026
Coordinator
Ignasi Roca
Funded by
Ministerio de Ciencia, Innovación y Universidades / Unión Europea / Agencia Estatal de Investigación (Ayuda PID2021-127402OB-I00)

The rise of antibiotic resistance represents a serious public health issue, and it is increasingly common to encounter patients with infections caused by bacteria that cannot be treated with any available antibiotic. This issue results in longer hospitalization times and associated mortality. The increase of hospital infections and resistance over all is mainly associated with the group of pathogenic bacteria known as ESKAPE, for their ability to evade the effect of antibiotics and to disseminate within hospitals. It is urgent to develop novel therapeutic strategies to treat patients infected by these microorganisms, but the prompt identification of such pathogens is also essential in order to preserve critical antibiotics and to rapidly activate prevention and infection control measures to contain their further spread.

During the last three years our team has monitored and collected the main antibiotic resistant bacteria spreading among a network of 22 healthcare facilities within Catalonia. We have identified the main mechanisms of resistance and the different clonal lineages disseminating in our centers. Nevertheless, we still lack a tool to identify such high-risk clones in order to implement control measures fast enough.

In this project we intend to use Fourier-transform Infrared (FTIR) spectroscopy to determine the clonal relatedness of bacterial isolates in real-time. This method detects the absorption of infrared light associated with the molecular vibration of the different molecules within the sample, thus generating a particular spectrum that constitutes a fingerprint for each strain. Bacterial isolates from the same clonal lineage or that share certain characteristics, such as antibiotic resistance, will show a similar absorption profile and we will be able to quantify their degree of relatedness and cluster them into particular categories, such as species, clonal group, capsular type, or resistance against a particular antibiotic. Therefore, by combining genomic, clinical and phenotypic data together with FTIR spectra, we will generate a database that should allow us to analyze the local epidemiology of all participant hospitals as well as to identify almost immediately (in real-time) any new isolate and relate it to the main circulating ESKAPE clones or identify certain characteristics that are of clinical relevance.

In the short run, such methodology should allow the rapid detection of bacterial outbreaks, thus reducing the time to activate prevention and infection control measures and improving our ability to prevent the spread of ESKAPE pathogens.

In the long run, we aim at reducing morbidity and mortality associated with infectious diseases caused by ESKAPE microorganisms as well as improve our understanding of the local epidemiology of such bacteria and their main transmission routes.

 

Total Fuding

108.900,00 €

 


 

Our Team

Coordinator

ISGlobal Team

Other projects

See Past Projects

MCC-Spain

Population based multicasecontrol study on common tumours in Spain

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohort of COVID-19 in Spain: social dynamics, mental health and inequalities

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health

IHEN

International Human Exposome Network

B-Triage

Una prueba en el punto de atención para la estratificación del riesgo de los pacientes febriles basada en los niveles de sTREM-1

e-QuoL

e-health tools to promote Equality in Quality of Life for childhood to young adulthood cancer patients, survivors and their families

AM-MENTAL

What happens with your mental health when your supervisor is an algorithm?