Publicador de continguts

Recerca i Innovació Programes
Recerca

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

Projecte AURORA 2021
Foto: Jr Korpa / Unsplash
Durada
01/04/2021 - 31/03/2026
Coordinador
Martine Vrijheid
Finançadors
Horizon 2020 - European Commission

The scale of micro- and nanoplastic pollution (MNP) is becoming increasingly clear yet little is known about how this pollution impacts health.

The AURORA project will deliver an actionable European roadmap for early-life health risk assessment of MNPs to support regulation of MNPs and the products and processes that generate secondary MNPs, and development of safer alternatives.

We will focus on MNP exposures and toxicological and health effects during pregnancy, in utero, and in early life. These periods are critical for development and health later in life and are of heightened vulnerability to environmental insults. We have recently shown that MNPs are likely to cross the placental barrier in vitro and in vivo, underlying the urgent need to understand the impact of MNPs on reproductive and early-life health.

AURORA will do so by significantly enhancing exposure assessment capabilities for measuring MNPs and MNP-associated chemicals (e.g. additives) in tissues relevant for early-life development (placenta, cord blood, amniotic fluid, meconium, fetal tissue). It will take a unique approach by combining in-depth characterization methods (microscopy and spectroscopy) and scalable methods (mass-spectrometry) to develop methods for both detailed and large-scale toxicological, exposure assessment, and epidemiological studies. This will be combined with a novel tiered-testing approach and epidemiological investigations to provide the first extensive evaluation of maternal and fetal MNP exposures and health perturbations, including placental function, immune-inflammatory responses, oxidative stress, accelerated aging, endocrine disruption, and child development.

In the course of developing and applying the tools and methodological workflows of the AURORA research program, we will create a risk assessment framework specific to MNPs and identify the remaining knowledge gaps and priorities needed for comprehensively evaluating the impact of MNPs on early-life health.

Funding

Total: 5,996,315.00 €

ISGlobal: 310,703.75 €

Our Team

Coordinator

  • Martine Vrijheid
    Martine Vrijheid Research Professor i directora del Programa de Medi ambient i salut al llarg de la vida

ISGlobal Team

Altres projectes

Veure projectes passats

MCC-Spain

Estudi multi-cas control poblacional, incloent tumors d'alta incidència a Espanya

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohort de COVID-19 a Espanya: dinàmica social, salut mental i desigualtats

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health

IHEN

International Human Exposome Network

B-Triage

Una prueba en el punto de atención para la estratificación del riesgo de los pacientes febriles basada en los niveles de sTREM-1

e-QuoL

e-health tools to promote Equality in Quality of Life for childhood to young adulthood cancer patients, survivors and their families

AM-MENTAL

Com afecta la teva salut mental que el teu cap sigui un algoritme?