Tuberculosi

L'estratègia actual de l'OMS (END-TB) busca reduir la incidència i mortalitat de la TB un 90 i 95%, respectivament, per al 2035 (relatiu a les xifres del 2015). Aquesta acceleració en els esforços de control de TB no serà possible sense una vacuna millorada. A més del desenvolupament i implementació d'una vacuna eficaç, el compliment de les metes globals de control i eliminació necessitarà el desenvolupament de noves proves diagnòstiques fàcils d'usar, règims més curts per a tractar tuberculosis susceptibles o resistents als fàrmacs, i un millor accés al diagnòstic. 

Les infeccions micobacterianes causades per Mycobacteria no tuberculosa (MNT) estan augmentant a nivell global, especialment en pacients amb malaltia pulmonar obstructiva crònica (EPOC) o bronquièctasi, resultant en llargs tractaments sense perspectiva de curació. 

Amb qui colaborem

Principals línies de treball

• Determinar càrrega de la malaltia en poblacions vulnerables (infantil, infectada amb VIH, embarassades)
• Avaluar impacte d'estratègies innovadores per a la recerca activa de casos basada en paràmetres espacials, densitat de població i càrrega microbiana en casos índex
• Avaluar noves eines de diagnòstic en contextos d'alta prevalença de TB i VIH
• Avaluar nous biomarcadors per al diagnòstic i tractament de TB

• Mariner-Llicer C, Goig GA, Torres-Puente M, Vashakidze S, Villamayor LM, Saavedra-Cervera B, Mambuque E, Khurtsilava I, Avaliani Z, Rosenthal A, Gabrielian A, Shurgaia M, Shubladze N, García-Basteiro AL, López MG, Comas I. Genetic diversity within diagnostic sputum samples is mirrored in the culture of Mycobacterium tuberculosis across different settings. Nat Commun 2024;15(1):7114.
• Centner CM, Munir R, Tagliani E, Rieß F, Brown P, Hayes C, Dolby T, Zemanay W, Cirillo DM, David A, Schumacher SG, Denkinger CM, Ruhwald M, Leukes VN, Nicol MP, Van der Walt I, Kisten G, Gumede M, Mace A, Brink A, Stevens W, Scott L, Penn-Nicholson A, Cox H; TB-CAPT Consortium (including Garcia-Basteiro AL). Reflex Xpert MTB/XDR Testing of Residual Rifampicin-Resistant Specimens: A Clinical Laboratory-Based Diagnostic Accuracy and Feasibility Study in South Africa. Open Forum Infect Dis 2024;11(8):ofae437.
• Mangu C, Cossa M, Ndege R, Khosa C, Leukes V, de la Torre-Pérez L, Machiana A, Kivuma B, Mnzava D, Zachariah C, Manjate P, Tagliani E, Schacht C, Buech J, Singh S, Ehrlich J, Riess F, Sanz S, Kranzer K, Cox H, Sabi I, Nguenha D, Meggi B, Weisser M, Ntinginya N, Schumacher S, Ruhwald M, Penn-Nicholson A, Garcia-Basteiro AL; TB-CAPT Consortium. Expanding Xpert MTB/RIF Ultra® and LF-LAM testing for diagnosis of tuberculosis among HIV-positive adults admitted to hospitals in Tanzania and Mozambique: a randomized controlled trial (the EXULTANT trial). BMC Infect Dis. 2024;24(1):831
• Churchyard GJ, Houben RMGJ, Fielding K, Fiore-Gartland AL, Esmail H, Grant AD, Rangaka MX, Behr M, Garcia-Basteiro AL, Wong EB, Hatherill M, Mave V, Dagnew AF, Schmidt AC, Hanekom WA, Cobelens F, White RG. Implications of subclinical tuberculosis for vaccine trial design and global effect. Lancet Microbe 2024:S2666-5247(24)00127-7.
• Gómez-Valverde JJ, Sánchez-Jacob R, Ribó JL, Schaaf HS, García Delgado L, Hernanz-Lobo A, Capellán-Martín D, Lancharro Á, Augusto O, García-Basteiro AL, Santiago-García B, López-Varela E, Ledesma-Carbayo MJ. Chest X-Ray-Based Telemedicine Platform for Pediatric Tuberculosis Diagnosis in Low-Resource Settings: Development and Validation Study. JMIR Pediatr Parent 2024:7:e51743.
• Martinez L, Seddon JA, Horsburgh CR, Lange C, Mandalakas AM; TB Contact Studies Consortium (including Garcia-Basteiro AL). Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosis infection status: a systematic review and individual-participant data meta-analysis of contact tracing studies. Lancet Respir Med. 2024:S2213-2600(24)00083-3.
• Garcia-Basteiro AL, Ehrlich J, Bonnet M, Calnan M, Graham SM, Hermans S, Jarrett A, Lewa R, Mandalakas A, Martinez L, Migliori GB, Ong CWM, Otero L, Rangaka MX, Raviglione MCB, Seaworth B, Ssengooba W, Theron G, Trajman A, Behr MA. A Global Tuberculosis Dictionary: unified terms and definitions for the field of tuberculosis. Lancet Glob Health 2024:S2214-109X(24)00083-4.
• Sequera G, Estigarribia-Sanabria G, Aguirre S, Piñanez C, Martinez L, Lopez-Olarte R, Andrews JR, Walter KS, Croda J, Garcia-Basteiro AL. Excess tuberculosis risk during and following incarceration in Paraguay: a retrospective cohort study. Lancet Reg Health Am 2024:31:100668
• Martín Pérez C, Aguilar R, Jiménez A, Salmerón G, Canyelles M, Rubio R, Vidal M, Cuamba I, Barrios D, Díaz N, Santano R, Serra P, Santamaria P, Izquierdo L, Trilla A, Vilella A, Barroso S, Tortajada M, García-Basteiro AL, Moncunill G, Dobaño C. Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination BMC Med 2024 ;22(1):103.
• Kay A, Vasiliu A, Carratala L, Mtafya B, Mendez Reyes JE, Maphalala N, Munguambe S, Mulengwa D, Ness T, Saavedra B, Bacha J, Maphalala G, Mejia R, Mtetwa G, Acacio S, Manjate P, Mambuque E, Shiba N, Kota N, Ziyane M, Elias NN, Lange C, Kirchner HN, DiNardo AR, Garcia-Basteiro AL, Mandalakas AM, for the Stool4TB Global Partnership. Performance of a stool-based quantitative polymerase chain reaction assay for the diagnosis of tuberculosis: a multinational prospective study of diagnostic accuracy in adolescents and adults. The Lancet Microbe 2024:S2666-5247(23)00391-9.
• Carratala-Castro L, Ssengooba, Kay, Acácio S, Ehrlich J DiNardo AR, Shiba N, Nsubuga JK, Munguambe S, Saavedra B, Mandjate P, Mulengwa D, Sibandze B, Ziyane M, Kasule, Mambuque E, Sekadde MP, Wobudeya E, Joloba ML, Heyckendorf J, Lange C, Hermans S, Mandalakas A, García-Basteiro AL, Lopez-Varela E on behalf of Stool4TB Global Partnership. A Stool based qPCR for the diagnosis of TB in children and people living with HIV in Uganda, Eswatini and Mozambique (Stool4TB): a protocol for a multicenter diagnostic evaluation. BMC Infec Dis, 2024. 24(1):233.
• Sequera G, Aguirre S, Estigarribia G, Walter KS, Horna-Campos O, Liu YE, Andrews JR, Croda J, Garcia-Basteiro AL. Incarceration and TB: the epidemic beyond prison walls. BMJ Glob Health 2024;9(2):e014722
• Saavedra B, Nguenha D, de la Torre-Pérez L, Mambuque E, Tembe G, Oliveras L, Rudd M, Philimone P, Jose B, Garcia JI, Gomes N, Munguambe S, Chiconela H, Nhanommbe M, Izco S, Acacio S, García-Basteiro AL. Improving tuberculosis case detection through contact risk stratification by Xpert MTB/RIF Ultra and spatial parameters: evaluation of an innovative active case finding strategy in Mozambique (Xpatial-TB). PLOS Glob Public Health. 2024: 4(2):e0002789
• Cossa M, Nguenha D, Houana A, Ehrlich J, Acácio S, Garcia-Basteiro AL. The urgent need to improve on low implementation rates for TB preventive treatment for people living with HIV. Int J Tuberc Lung Dis 2024: 28(1):1-2.
• White RG, Fiore-Gartland AJ, Hanekom WA, Vekemans J, Garcia-Basteiro AL, Churchyard G, Rangaka MX, Frick M, Behr MA, Hill PC, Mave V. What is next for BCG revaccination to prevent tuberculosis? Lancet Respir Med 2024 :S2213-2600(24)00009-2.
• Leukes VN, Hella J, Sabi I, Cossa M, Khosa C, Erkosar B, Mangu C, Siyame E, Mtafya B, Lwilla A, Viegas S, Madeira C, Machiana A, Ribeiro J, Garcia-Basteiro AL, Riess F, Elísio D, Sasamalo M, Mhalu G, Denkinger CM, Castro MDM, Bashir S, Schumacher SG, Tagliani E, Malhotra A, Dowdy D, Schacht C, Buech J, Nguenha D, Ntinginya N, Ruhwald M, Penn-Nicholson A, Kranzer K; TB-CAPT Consortium. Study protocol: a pragmatic, cluster-randomized controlled trial to evaluate the effect of implementation of the Truenat platform/MTB assays at primary health care clinics in Mozambique and Tanzania (TB-CAPT CORE). BMC Infect Dis. 2024: 19;24(1):107
• Mariner-Llicer C, Saavedra Cervera B, Mambuque E, Gomes N, Munguambe S, Villamayor L, Cancino-Muñoz I, Torres-Puente M, Nguenha D, Respeito D, Tembe G, López MG, Comas I, García-Basteiro AL. Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique. Clin Infect Dis, 2024;78(4):842-845.
• Hill PC, Cobelens F, Martinez L, Garcia-Basteiro AL, Behr M, Rangaka MX, Churchyard G, Evans T, Hanekom W, White R. Correspondence Regarding: McShane H. Improving TB vaccine trial efficiency: A tough nut to crack. J Infect Dis 2024;229(2):616.

Aquí trobaràs totes les publicacions entre 2014 i 2024: