Asset Publisher

Research & Innovation Programmes
Research, Maternal, Child and Reproductive Health

MULTIPLY

MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention

Duration
01/05/2021 - 31/08/2024
Coordinator
Clara Menéndez
Funded by
The European & Developing Countries Clinical Trials Partnership (EDCTP)
Website
https://multiplyipti.net

As efforts to control malaria are stalling, and the disease is particularly severe in children under the age of two, it is imperative for countries in sub-Saharan Africa, with areas of moderate-to-high transmission, to implement Intermittent Preventive Treatment in infants (IPTi) delivered through the Expanded Program on Immunization (EPI), which is the only feasible, sustainable and cost-effective strategy to reach this high-risk group. IPTi has been shown to be safe, efficacious in reducing clinical malaria, anaemia and hospital admissions, and to be highly cost-effective since it is delivered alongside EPI and uses an inexpensive antimalarial drug (Sulfadoxine-Pyrimethamine); for all these reasons, the World Health Organisation recommends it for malaria prevention in infants. However, IPTi has not been implemented to date, except in Sierra Leone.

MULTIPLY is a large-scale implementation development cooperation project, which includes public and private European and African institutions aiming at maximising the delivery and uptake of IPTi, to achieve full potential and effectiveness of this intervention.

Research partners from Mozambique, Sierra Leone and Togo in selected country districts will conduct the implementation of IPTi at health facilities and EPI mobile-outreach clinics using a paediatric dispersible formulation of SP, alongside routine vaccinations and vitamin A supplementation. Children will receive up to a maximum of 6 doses of IPTi in the first two years of life.

Through this implementation, capacity will be built and fundamental programmatic issues to achieving effectiveness will be assessed, including:

  • IPTi operational feasibility and acceptability;
  • impact on health services integration, i.e. on EPI immunisations and vitamin A administration coverage;
  • the cost and cost-effectiveness of IPTi delivery including through the outreach EPI platform;
  • the impact on malaria incidence, anaemia, overall mortality, SP resistance development and the safety of the intervention.

The integration of IPTi with EPI contacts, together with social and behaviour change communication campaigns to inform communities of the importance of EPI, and the malaria protection afforded by IPTi delivered at the EPI, could lead to an increased demand for EPI.

Total Funding

4,722,431 €

 

This project is part of the EDCTP2 programme supported by the European Union

 

 

Our Team

Coordinator

  • Clara Menéndez Santos
    Clara Menéndez Santos

ISGlobal Team

See More

Other projects

See Past Projects

NHEPACHA

New Tools for the Diagnosis and Evaluation of Chagas Disease

RTS,S Vaccine Immunology Study

Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial

Euroleish.net

Control of Leishmaniasis. From bench to bedside and community

GREPIMER

Grup de recerca en patología importada i malaties emergents i re-emergents

TESEO

New chemotherapy regimens and biomarkers for Chagas Disease

ASINTMAL

Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults

ADAM

Malaria mass and focal drug administration to advance malaria elimination in Mozambique: accelerating programmatic implementation and policy translation

Science4Pandemics

Citizens engagement digital platform for collective intelligence in pandemics

HIDDENVIVAX

Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria

EpiGen

Building Scalable Pathogen Genomic Epidemiology in Ethiopia

MalTransc

Transcriptional regulation of adaptation and developmental decisions in malaria parasites: from epigenetic variation to directed transcriptional responses

BOHEMIA

Broad One Health Endectocide-based Malaria Intervention in Africa

RESPONSE

Mechanisms of the transcriptional responses to changes in the environment in the malaria parasite Plasmodium falciparum

VivaxEVTalk

Extracellular Vesicles as Intercellular Communicators and Biomarkers of Cryptic Erythrocytic Infections in Plasmodium vivax malaria

VaMonoS

Unravelling the heterogoneity and function of monocytes in vaccination and immunity to malaria

CLIMSOCTRYPBOL

Insight on climate and social participatory research for integral management of vectorborne zoonosis caused by Trypanosoma cruzi and Leishmania spp. in the Bolivian Gran Chaco.

SexMal

Social affairs and sex in P. falciparum: implications for malaria elimination

MENA Migrant Health

Transforming data collection and surveillance to drive migrant health research, care and policy

MESA

Sharing knowledge and catalyzing research towards a malaria-free world

GenMoz

P. falciparum genomic intelligence in Mozambique

SMART

Identifying Severe Malaria with a new Aptamer-based Rapid diagnostic Test

CaDMIA-plus

Continued validation of the minimally invasive autopsy for the investigation of the causes of death in infants, and establishment of a research and training center to study causes of death

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

ICARIA

Improving Care through Azithromycin Research for Infants in Africa

MIBio

Identification of Prematurity and Pre-Eclampsia as Causes of Mortality

MA-CoV

Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations

IPERVAC-SL

Impact of perceptions of COVID-19 vaccines on health-seeking behaviours in Sierra Leone

RESPIRE

Respiratory syncytial virus (RSV) in African pregnant women and children

VITAL

Towards preparedness for new maternal vaccinations: Understanding barriers and facilitators to maternal vaccine acceptance

HIV drug resistance (HIVDR)

Description of HIV drug resistance patterns and its association with the risk of HIV mother to child transmission among pregnant women from southern Mozambique

PROTECT

PReparing for Optimal Phase III/IV maTErnal Group B StreptococCal vaccine Trials in Africa