Exposure to Heat and Cold During Pregnancy Associated with Changes in Foetal Growth

A new study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, has investigated the relationship between exposure to ambient air temperature and foetal size and growth during pregnancy. The results, published in Environment International, show that cumulative exposure to heat and cold is associated with changes in foetal head circumference, a measure linked to brain development.

The study used data from 23,408 pregnant women from three European birth cohorts: the English Born in Bradford cohort, the Dutch Generation R study, and the Spanish INMA - Environment and Childhood project. The UrbClim™ model was used to calculate weekly exposure to ambient temperature at the mothers' homes during pregnancy. Foetal measures from ultrasound examinations at mid and late pregnancy, including estimated foetal weight, head circumference, and femur length, were analysed. Foetal growth from mid to late pregnancy was calculated and weight, head circumference, and length at birth were also analysed.

The results showed an association between exposure to hotter temperatures and larger head circumference at late pregnancy. Colder temperatures were associated with smaller head circumference at late pregnancy and a slower growth in head circumference from mid to late pregnancy.

The team observed specific periods of vulnerability to cold during the first trimester of pregnancy, when several foetal brain development processes take place. Specifically, susceptibility periods for exposure to cold were identified during pregnancy weeks 1 to 7 for a smaller head circumference at late pregnancy and weeks 4 to 12 for a slower head circumference growth.

Long-term implications

The team found no associations between ambient air temperature and birth outcomes, suggesting that the effects observed during pregnancy may recover at birth. "However, the identified effects of temperature on foetal development may become more prominent in magnitude and duration, especially in the context of worsening climate change" says Esmée Essers, ISGlobal researcher and first author of the study.

The results of this study highlight the importance of further research into the link between temperature exposure and foetal size and growth by replicating this study in different climatic regions.

"This work is important because we need to better understand how and when temperature can affect the foetus, to identify the underlying biological mechanisms and to provide a basis for climate change mitigation strategies for pregnant women and their future children," says Mònica Guxens, ISGlobal researcher and last author of the study.

Reference

Essers, E., Granés, L., Delaney, S., Ballester, J., Santos, S., Petricola, S., C Yang, T., Fernández-Somoano, A., Bereziartua, A., Ballester, F., Tardón, A., Vrijheid, M., Lertxundi, A., McEachan RC, R., El Marroun, H., Tiemeier, H., Iñiguez C., Guxens, M. Ambient air temperature exposure and foetal size and growth in three European birth cohorts. Environment International, Volume 186, April 2024. Doi: 10.1016/j.envint.2024.108619