Publicador de contenidos

Investigación e Innovación Programas
Salud Materna, Infantil y Reproductiva

PERS (bordetella PErtussis and Respiratory Syncytiual virus in pregnant women and their infants)

Contributing to the road map of maternal immunization: Determining the burden of Bordetella pertussis, respiratory syncytial virus (RSV) and Influenza virus in pregnant women and their infants in Mozambique

Duración
03/2017 - 03/2018
Coordinador
Azucena Bardají
Financiadores
MINECO / Women in Science-UNESCO. L'Oreal Foundation

Maternal immunization represents a unique opportunity to protect pregnant women and their babies from diseases that cause substantial morbidity and mortality. Currently inactivated influenza, tetanus toxoid and acellular pertussis vaccines are recommended during pregnancy. Tetanus toxoid is the only widely implemented in low-income countries. Other vaccines under evaluation or in development for potential maternal immunization include group B Streptococcus, and respiratory syncytial virus (RSV). Acute respiratory infections such as those associated to Bordetella pertussis and RSV are among the most important causes responsible for morbidity and mortality during the first months of life. Pertussis is a highly infectious and severe respiratory disease than can be fatal in young infants, and currently and emergent global health problem.

This study aims to understand the burden and epidemiology of Bordetella pertussis, RSV and Influeza virus in pregnant women and young infants from Mozambique as site preparation investment for the evaluation of new vaccines during pregnancy to protect mothers, infants or both. The will be an observational, prospective study that will be conducted by the Manhiça Health Research Centre (CISM) and ISGlobal at the Manhiça District Hospital over 12 months, and that will enroll 250 pregnant women and their infants. The prevalence of infection by Bordetella pertussis, VRS and influenza virus will be determinated in pregnant women at the time of delivery, as well as in their infants after birth. The incidence of acute respiratory infections due to pertussis, VRS and influenza virus over the first 90 days of life will be determined among infants born to study women. The role of HIV and malaria in modifying the burden of pertussis, RSV and influenza virus will be also investigated. 

 

Nuestro equipo

PI

ISGlobal team

  • Clara Menéndez Santos
    Clara Menéndez Santos
  • Elena Marban Castro
    Elena Marban Castro

Otros proyectos

Ver proyectos pasados

COMBACTE

Combatiendo la Resistencia Bacteriana en Europa

GAMA

Development of Novel Gastrointestinal Biomarkers for Use in HIV Incidence Determination in a Sub-Saharan African Setting

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

ICARIA

Improving Care through Azithromycin Research for Infants in Africa

PreFIT

Predicting the Future: Incipient Tuberculosis

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

ENDÈMIC

Community knowledge generation through scientific culture, urban ecology and art

EpiGen

Building Scalable Pathogen Genomic Epidemiology in Ethiopia

Hepatitis C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.

FLAVOBAC

Nuevas moléculas de oro coordinadas con flavonoides contra bacterias patógenas multirresistentes prioritarias

CaDMIA-plus

Validación continuada de la autopsia mínimamente invasiva (MIA) para la investigación de la causa de muerte en niños pequeños, y desarrollo de un centro de investigación y formación sobre el estudio de la causa de muerte

MIBio

Identification of Prematurity and Pre-Eclampsia as Causes of Mortality

MULTIPLY

MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention

MA-CoV

Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations

IPERVAC-SL

Impact of perceptions of COVID-19 vaccines on health-seeking behaviours in Sierra Leone

RESPIRE

Respiratory syncytial virus (RSV) in African pregnant women and children

VITAL

Towards preparedness for new maternal vaccinations: Understanding barriers and facilitators to maternal vaccine acceptance

HIV drug resistance (HIVDR)

Description of HIV drug resistance patterns and its association with the risk of HIV mother to child transmission among pregnant women from southern Mozambique

PROTECT

PReparing for Optimal Phase III/IV maTErnal Group B StreptococCal vaccine Trials in Africa