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Georgios Koutsoudakis

Georgios Koutsoudakis

Investigador postdoctoral

Dr. Georgios Koutsoudakis is a biomedical researcher with a strong background in molecular and cellular biology, virology and immunology acquired in 3 different countries (Germany, Italy and Spain). His scientific portfolio includes 33 scientific articles and 20 non- and competitive scientific projects (team member). During 2015-2020, his work was focused on the immunopathology caused by chronic viral hepatitis infections, and specifically on understanding mechanisms of perturbations and restoration of immune system homeostasis during and after antiviral treatments.
Of note, during the last 2.5 years, his research focused on delineating the immunopathology of patients with autoimmune hepatitis (Co-PI of the research project FIS PI021/0800). Within this grant, we  has included strategies in order to analyze at a single cell resolution level the T cell repertoire infiltrated in liver biopsies of patients diagnosed with autoimmune hepatitis.
Dr. Georgios Koutsoudakis joined the Malaria Immunology group under the supervision of Prof. Carlota Dobaño and Dr. Gemma Moncunill,  as a senior T cell post-doc immunologist. His future research will include analyses of  i) T cell profiling in PBMCs acquired from COVID-19 cohorts and ii) T cell repertoires in malaria and helminth endemic and vaccinated populations. 

Líneas de investigación

  • Immunophenotyping of T cells acquired from HCW
  • Sars-Cov-2 responses longitudinal analysis
  • Comprehensive analysis of T cells in Long Covid
  • T cell repertoire analysis in malaria and helminth vaccinated population

Principales publicaciones

  • Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients. García-López M, Lens S, Pallett LJ, Testoni B, Rodríguez-Tajes S, Mariño Z, Bartres C, García-Pras E, Leonel T, Perpiñán E, Lozano JJ, Rodríguez-Frías F, Koutsoudakis G, Zoulim F, Maini MK, Forns X, Pérez-Del-Pulgar S. J Hepatol. 2021 May;74(5):1064-1074. doi: 10.1016/j.jhep.2020.11.043. Epub 2020 Dec 2. PMID: 33278456 
  • Chronic genotype 1 hepatitis C along with cirrhosis drives a persistent imprint in virus-specific CD8+ T cells after direct-acting antiviral therapies. Perpiñán E, Pérez-Del-Pulgar S, Londoño MC, Mariño Z, Lens S, Leonel T, Bartres C, García-López M, Rodriguez-Tajes S, Forns X, Koutsoudakis G. J Viral Hepat. 2020 Dec;27(12):1408-1418. doi: 10.1111/jvh.13370. Epub 2020 Aug 18. PMID: 32812325
  • Cirrhosis Hampers Early and Rapid Normalization of Natural Killer Cell Phenotype and Function in Hepatitis C Patients Undergoing Interferon-Free Therapy. Perpiñán E, Pérez-Del-Pulgar S, Londoño MC, Mariño Z, Bartres C, González P, García-López M, Pose E, Lens S, Maini MK, Forns X, Koutsoudakis G. Front Immunol. 2020 Feb 25;11:129. doi: 10.3389/fimmu.2020.00129. eCollection 2020. PMID: 32161581 
  • Hepatitis A outbreak in Barcelona among men who have sex with men (MSM), January-June 2017: A hospital perspective. Rodríguez-Tajes S, Perpiñán E, Caballol B, Lens S, Mariño Z, Costa J, Vilella A, Pérez-Del-Pulgar S, Forns X, Koutsoudakis G. Liver Int. 2018 Apr;38(4):588-593. doi: 10.1111/liv.13606. Epub 2017 Nov 10. PMID: 28980376
  • Occult Hepatitis C Virus Infection: Are We Digging Too Deep? Koutsoudakis G, Pérez-Del-Pulgar S, Forns X. Gastroenterology. 2017 Feb;152(3):472-474. doi: 10.1053/j.gastro.2016.12.015. Epub 2016 Dec 27. PMID: 28038930
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