Research, Maternal, Child and Reproductive Health

Descripción del patrón de resistencias a fármacos anti-VIH y asociación con el riesgo de transmisión vertical en gestantes del sur de Mozambique

Duration: 01/01/2023 - 31/12/2025
Coordinator: Raquel González
Funded by: Proyecto PI22/01028

Antecedentes

El desarrollo de farmacorresistencias del VIH (FRVIH) puede comprometer la eficacia de la terapia antirretroviral (TAR).

Dicho hecho es particularmente importante en las mujeres embarazadas del África subsahariana debido a la alta carga de infección presente en la región y al riesgo de transmisión vertical del VIH

Objetivo

Describir la prevalencia y las características de las mutaciones de la FRVIH en mujeres embarazadas de Mozambique antes y después de la implementación del uso de dolutegravir (DTG) en el país, y evaluar su asociación con el riesgo de transmisión vertical del VIH a través de la lactancia.

Métodos

Se analizarán muestras de plasma de 200 mujeres embarazadas infectadas por el VIH con fracaso virológico (carga viral del VIH > 50 c/ml). Las mutaciones relacionadas con las FRVIH se determinarán utilizando MiSeq® en muestras obtenidas en la primera visita prenatal y en el momento del parto. En una submuestra de participantes también se analizará la presencia del VIH en la leche materna.

Financiación total

123.420,00 EUR

Coordinador

Raquel González Associated Researcher

Equipo de ISGlobal

Aina Casellas Torrento Biostatistic Technician
Antía Figueroa Research Technician

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Antecedentes

Objetivo

Métodos

Financiación total

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Coordinador

Equipo de ISGlobal

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