Recerca

FLAVOBAC

Nuevas moléculas de oro coordinadas con flavonoides contra bacterias patógenas multirresistentes prioritarias

Foto: Canva

Durada: 01/01/2023 - 31/12/2025
Coordinador: Sara Soto
Finançadors: EU Horizon 2020: Ayuda PI22/00148

Las bacterias resistentes a los antibióticos (ARB) son una amenaza global para la salud humana que causa 1,27 millones de muertes en todo el mundo. Si no se toman medidas, antes de 2050, 10 millones de personas podrían morir cada año en todo el mundo por ARB. Staphylococcus aureus resistente a meticilina y Acinetobacter baumannii resistente a carbapenems son dos patógenos clínicamente problemáticos considerados prioritarios por la OMS. Esto significa que nuestra capacidad para combatir las infecciones causadas por ellos con nuestro actual arsenal de antibióticos está disminuyendo.

Objetivo

Aquí, proponemos el desarrollo de nuevos complejos resultantes de la coordinación de complejos de oro(III) con flavonoides que podrían ser una estrategia prometedora para la obtención de nuevos fármacos contra bacterias resistentes y biopelículas bacterianas. Para ello, se realizará el diseño y síntesis de los nuevos complejos, se analizará la actividad antibacteriana y antibiopelículas, la toxicidad, así como la efectividad en modelos animales in vivo de los más prometedores.

Además, se ensayarán terapias combinadas con antibióticos de uso clínico para mejorar la actividad antibacteriana. Los resultados esperados serán de alto valor social ya que el desarrollo de una nueva clase de antibióticos mejorará radicalmente la salud de los pacientes, disminuyendo el fracaso del tratamiento, los días de hospitalización, reduciendo los costes sanitarios asociados a estas infecciones.

Grupo de investigación

Resistencia antimicrobiana

Financiación total

117.370,00 EUR

Coordinador

Sara Soto González Associate Research Professor i directora del Programa d'Infeccions Víriques i Bacterianes

Equipo de ISGlobal

Yaiza Gabasa Tècnica de laboratori

Altres projectes

Veure projectes passats

COMBACTE

Combatent la Resistència Bacteriana a Europa

GAMA

Development of Novel Gastrointestinal Biomarkers for Use in HIV Incidence Determination in a Sub-Saharan African Setting

Desenvolupament d'estratègies per a l'Eradicació de la Malaltia de Pian

Eradicació del Pian

Novel Marine Biomolecules against Biofilm (NoMorFilm)

Application to medical devices

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

ICARIA

Improving Care through Azithromycin Research for Infants in Africa

PreFIT

Predicting the Future: Incipient Tuberculosis

Encuesta serológica Cendea de Cizur

Cendea de Cizur

Projecte de Recerca en Resposta Immunitària i Epidemiologia de Malalties Infeccioses

Conèixer la propagació. Entendre la protecció

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

ALIA - Las ciudades y la salud

Planificación urbana, medio ambiente y salud | Clima y salud | Resistencias Antimicrobianas

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

Estudio de la propagación de bacterias y genes de resistencia a los antibióticos en el ciclo integral del agua, en el área metropolitana de Barcelona

Propagación de la resistencia en aguas

Nuevos complejos de oro (III) frente a bacterias multirresistentes

Project Code: DTS21/00004

Desarrollo de dos nuevas estrategias terapéuticas (inhibidores de bombas de expulsion y ARN antisentido) activos frente a bacterias mutliresistentes

Más allá de la supresión vírica del VIH: un cuarto noventa para mejorar la salud de personas viviendo con el VIH en España

Project Code: PI20/01654

Evaluación de la eficacia del ácido acetilsalicílico a dosis bajas en la prevención de los efectos maternos y perinatales adversos en mujeres embarazadas infectadas por el SARS-CoV-2

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Objetivo

Grupo de investigación

Financiación total

Our Team

Coordinador

Equipo de ISGlobal

Altres projectes

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