Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
- Durada
- 01/01/2017 - 31/12/2019
- Coordinador
- Sara M. Soto
- Finançadors
- Instituto de Salud Carlos III (ISCIII)
Airways infection remains the leading cause of morbidity and mortality, estimated at 85% in patients with cystic fibrosis (CF).
Methicillin Resistant Staphylococcus aureus (MRSA), Haemophilus influenzae, Pseudomonas aeruginosa, Burkholderia cepacia complex, Stenotrophomonas maltophilia and non-tuberculosis mycobacteriae, are the main microorganisms involved in these infections. Respiratory microbiota of a CF patient is exposed to a strong antibiotic pressure due to frequent and prolonged treatments, leading to the emergence of antimicrobial resistance and the selection of highly resistant strains.
The main objective of this project is the research and development of functional gold complexes (metalantibiotcs) that are active against these microorganisms both in planktonic state and growing in biofilms. To do this, phenotypic methods directed to microbiological analysis of antomicrobial resistance (antibiogram), the analysis of resistance of biofilms (antibiofilmogram), the study of susceptibility against combinations of metalantibiotcs/conventional antibiotics, chemical methods for metalantibiotcs synthesis and development, as well as molecular methods such as genomics, will be used.
Total funding
157,602 €
Our Team
PI
-
Sara Soto Gonzalez
Team
-
Yuly De Los Angeles López Cubillos
-
GRISELDA TUDO Associated Researcher
Altres projectes
Veure projectes passatsCOMBACTE
Combatent la Resistència Bacteriana a Europa
GAMA
Development of Novel Gastrointestinal Biomarkers for Use in HIV Incidence Determination in a Sub-Saharan African Setting
Desenvolupament d'estratègies per a l'Eradicació de la Malaltia de Pian
Eradicació del Pian
Novel Marine Biomolecules against Biofilm (NoMorFilm)
Application to medical devices
COMBACTE-CARE
Combatting Bacterial Resistance in Europe - Carbapenem Resistance
MAMAH
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women
INTE-AFRICA
Integrating and decentralizing diabetes and hypertension services in Africa
ICARIA
Improving Care through Azithromycin Research for Infants in Africa
PreFIT
Predicting the Future: Incipient Tuberculosis
Predicting the Future: Incipient Tuberculosis
Encuesta serológica Cendea de Cizur
Cendea de Cizur
Projecte de Recerca en Resposta Immunitària i Epidemiologia de Malalties Infeccioses
Conèixer la propagació. Entendre la protecció
ANTICOV
Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19
Stool4TB
Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV
TB-RECONNECT
Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status
SToolNIH
Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring
ALIA - Las ciudades y la salud
Planificación urbana, medio ambiente y salud | Clima y salud | Resistencias Antimicrobianas
END-VOC
ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)
TwinAir
Digital Twins Enabled Indoor Air Quality Management for Healthy Living
Estudio de la propagación de bacterias y genes de resistencia a los antibióticos en el ciclo integral del agua, en el área metropolitana de Barcelona
Propagación de la resistencia en aguas
Nuevos complejos de oro (III) frente a bacterias multirresistentes
Project Code: DTS21/00004
Desarrollo de dos nuevas estrategias terapéuticas (inhibidores de bombas de expulsion y ARN antisentido) activos frente a bacterias mutliresistentes
Más allá de la supresión vírica del VIH: un cuarto noventa para mejorar la salud de personas viviendo con el VIH en España
Project Code: PI20/01654
ENDÈMIC
Community knowledge generation through scientific culture, urban ecology and art
EpiGen
Building Scalable Pathogen Genomic Epidemiology in Ethiopia
Hepatitis C Free Baleares
Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.
FLAVOBAC
Nuevas moléculas de oro coordinadas con flavonoides contra bacterias patógenas multirresistentes prioritarias