Oferta de trabajo: Immune Response and Biomarkers Core Facility Senior Technician

In the framework of our Centre for Excellence Severo Ochoa Programme (CEX2023-001290-S), ISGlobal is seeking a postdoctoral scientist who is interested in taking over a senior technician position at the new Immune Response and Biomarkers Core Facility at ISGlobal. This position will help to consolidate a platform of excellence to better integrate the research on biomarkers and immune responses on infectious diseases (IDs), exposome and NCDs. The goal of this Severo Ochoa action is to integrate current existing expertise and infrastructure in high-throughput miniaturised multiplex technologies for targeted proteomics (including cytokines and other biomarkers) and quantification of antibody responses, applying the x-MAP Luminex and Olink platforms, into a forefront core facility that will provide internal as well as external services, to foster interactions and partnerships, and raise opportunities for international visibility and leadership. Specific interest exists on establishing in-house expertise on expression of customised antigens and monoclonal antibodies to be used in immune assays (e.g. to detect ID exposures serologically), which at the moment represent a significant bottleneck for rapid response and preparedness in case of emergence of new pathogens of epidemic potential.

This position will be supported by funding from the “Centro de Excelencia Severo Ochoa 2024-2028” Program (CEX 2023-0001290-S) from the Spanish Ministry of Science and Innovation, and the Spanish Research State Agency (MCIN/AEI/10.13039/501100011033).

• PhD on biomedical sciences, biotechnology, microbiology or alike

• Extensive hands-on experience on immune assays and biomarker profiling, from protocol interpretation and development to experimental design, assay execution, troubleshooting
• Desirable: experience in multiplex technologies including Luminex assays
• Desirable: molecular biology and microbiology experience in cloning and expression of proteins
• Desirable: basic knowledge of softwares (GraphPad) and/or programming languages (e.g. R) for data QC, preprocessing and descriptive statistics
   

• Plan, develop and execute immunological assays and biomarker profiling as part of the portfolio of services at the ISGlobal Core Facility 
   

• Measurement of biomarkers of IDs, NCDs, exposome and immunopathology
• Measurement of pathogen antigens and antibodies as markers of infection, exposure and/or protection
• Write and update Standard Operating Procedures
• Prokaryotic and eukaryotic protein expression for production of antigens and antibodies to measure target molecules
• To support the setup and exploration of N-glycans as biomarkers in malaria, other IDs (such as Chagas and COVID-19), and post-vaccination responses, consolidating methods for glycan release, labeling, and analysis using capillary electrophoresis with fluorescently labeled glycan.
• Set up systems to explore N-glycans in the Fc region of IgGs as biomarkers.
• Explore the total plasma N-glycome as novel biomarkers.
• Implement tasks according to QA procedures (ISO 9001)
• Contribute to training and capacity building of researchers/technicians from low and middle income countries (LMIC)

This job description reflects the present requirements of the post but may evolve at any time in the future as duties and responsibilities change and/or develop providing there is appropriate consultation with the post-holder. 

This job description is not a definitive or exhaustive list of responsibilities but identifies the key responsibilities and tasks of the post holder. The specific objectives of the post holder will be subject to review as part of the individual professional assessment  process.

• Attention to detail
• Multitasking
• Hands ability and precision
• Teamwork
• Problem resolution and troubleshooting
• Planning and organization skills and meeting deadlines
• Learning and teaching capacity
• Interpersonal skills

The post holder will adhere to ISGlobal principles contained in People management policy, including Equity, diversity and health safety. The post holder will respect, and accountable to ensure ISGlobal policies and procedures .
 

• Written and oral English
• Desirable: Catalan and/or Spanish. Other languages (Portuguese etc) a plus

• Duration: 3/4 years      
• Starting date: October 2024    
• Contract: full time 
• Salary Range: According to experience and profile

Applicants must fill in the request form, attach the CV and a Cover Letter. Each attached document must be named with the candidate name and surname. 

The receipt of applications will be open until 15/09/2024.

Only the applications submitted through the request form will be considered.

Only shortlisted candidates will be contacted.

Diverse candidatures are encouraged, that includes: gender, race, ethnicity, religion, age, sexual orientation, physical abilities, and political views.

Please contact Giulia Pollarolo (giulia.pollarolo@isglobal.org) for questions about this position.

The selection process is designed in two phases:
1- Interview phase of a technical nature, with the team that requires the incorporation. To assess the person's skills and CV.
2 - Meeting with HR with the finalist(s) to finish assessing the profile and discuss contractual and institutional issues.

If needed any technical test could be pass. A Psychological Competency Evaluation Test will be required for the structural or transversal positions.
In accordance with the OTM-R principles, a gender-balanced recruitment panel is formed for every vacancy at the beginning of the process. After reviewing the content of the applications, the panel will start the interviews, with at least one technical and one administrative interview. A profile questionnaire as well as a technical exercise may be required during the process.

In ISGlobal we are committed to maintaining and developing a work environment in which the values and principles of our organization are respected and equal opportunities between women and men be promoted in each of the areas in which we operate, not tolerating discrimination based on criteria such as age, gender, marital status, race, ethnicity, functional diversity, political leanings, religion, sexual orientation, gender identity or gender expression.
ISGlobal supports the initiative #ScienceforUkraine. Therefore, to sustain Ukraine’s presence in the European Research Area and international scholarly community, candidates from Ukraine on all levels of scholarly career are welcome: students, PhD candidates, early career researchers and senior scholars.
We confirm our commitment towards the value of the diversity of our staff and student population and seek to promote peace, equity, diversity and inclusion as essential elements in contribution to improving health worldwide.