Publicador de contenidos

Investigación e Innovación Programas
Investigación, Salud Materna, Infantil y Reproductiva

TIPTOP

Transforming IPT for optimal pregnancy

Duración
01/05/2017-30/04/2022
Coordinador
Clara Menéndez
Financiadores
UNITAID
Página web
https://www.tiptopmalaria.org

In sub-Saharan Africa (SSA), over 30 million pregnant women are annually exposed to infection from malaria. Of these, an estimated 10,000 pregnant women and up to 200,000 newborns die from malaria in pregnancy (MiP), primarily due to the infection from Plasmodium falciparum bites. Furthermore, recent data indicate that up to 20% of stillbirths in SSA are attributable to MiP. In the broader framework of the 2030 agenda, the TIPTOP project is well aligned with the overall SDG3 health targets of accelerating maternal and newborn mortality reduction in the Sub Saharan region and reflects well how different stakeholders have a role and responsibility in helping to achieve these ambitious goals: from sub Saharan African countries to donors, international development and research partners.

IThis 5-year project, funded by UNITAID and implemented by Jhpiego (coordinator) and ISGlobal (research partner) in collaboration with the World Health Organization (WHO) and the Medicines for Malaria Venture (MMV), aims to increase intermittent preventive treatment in pregnancy (IPTp) for malaria with sulfadoxine-pyrimethamine (SP)—in addition to the use of insecticide-treated bed nets (ITNs) and effective case management IPTp coverage— and expand antenatal care attendance primarily through Community Health Workers in four Sub Saharan African countries: DRC, Mozambique, Madagascar and Nigeria. A learning-driven approach will be employed throughout the project to guide expansion in a two-phase process and generate sufficient evidence to inform WHO policy recommendations and future actions in each country, in an effort to expand the intervention over the long-term.

In an initial phase 10,000 pregnant women per country are expected to be reached (2 years). Then in the so-called expansion phase (3 years) 30,000 pregnant women per country will be enrolled. This project plans to engage community health workers to increase IPTp delivery and demand, catalyzing and further encouraging scale-up of IPTp in Africa. Additionally, it will expand antenatal care attendance in these four African countries.

ISGlobal is the lead evaluation and research organization and is responsible for implementing a set of studies to generate evidence for global guidance on community IPTp-SP. Specifically, ISGlobal will be responsible for designing and implementing the project’s evaluation plan, as well as designing, analyzing and reporting the operational research studies to assess the cost and acceptability of the intervention and its impact.

Total funding:

  • Total Project Funding: $50M
  • Total ISGlobal Funding: $10.4 M
 

More Information:

 

Nuestro equipo

PI

  • Clara Menéndez Santos
    Clara Menéndez Santos

ISGlobal team

Ver más

Otros proyectos

Ver proyectos pasados

ICARIA

Improving Care through Azithromycin Research for Infants in Africa

NHEPACHA

Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas

Estudio inmunológico de la vacuna RTS,S

Estudio de correlatos de protección frente a la malaria después de la vacunación con RTS,S/AS01E: Una evaluación inmunológica exhaustiva en el ensayo clínico de Fase III, doble ciego, aleatorizado, multicéntrico con un grupo control

Euroleish.net

Control of Leishmaniasis. From bench to bedside and community

GREPIMER

Grup de recerca en patología importada i malaties emergents i re-emergents

TESEO

Nuevos regímenes de quimioterapia y biomarcadores para la enfermedad de Chagas

ASINTMAL

Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults

ADAM

Administración masiva y focal de fármacos antimaláricos para avanzar hacia la eliminación de la malaria en Mozambique: acelerando la implementación de programas y políticas

MULTIPLY

MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention

Science4Pandemics

Citizens engagement digital platform for collective intelligence in pandemics

HIDDENVIVAX

Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria

EpiGen

Building Scalable Pathogen Genomic Epidemiology in Ethiopia

MalTransc

Transcriptional regulation of adaptation and developmental decisions in malaria parasites: from epigenetic variation to directed transcriptional responses

BOHEMIA

Broad One Health Endectocide-based Malaria Intervention in Africa

RESPONSE

Mechanisms of the transcriptional responses to changes in the environment in the malaria parasite Plasmodium falciparum

VivaxEVTalk

Extracellular Vesicles as Intercellular Communicators and Biomarkers of Cryptic Erythrocytic Infections in Plasmodium vivax malaria

VaMonoS

Unravelling the heterogoneity and function of monocytes in vaccination and immunity to malaria

CLIMSOCTRYPBOL

Insight on climate and social participatory research for integral management of vectorborne zoonosis caused by Trypanosoma cruzi and Leishmania spp. in the Bolivian Gran Chaco.

SexMal

Social affairs and sex in P. falciparum: implications for malaria elimination

MENA Migrant Health

Transforming data collection and surveillance to drive migrant health research, care and policy

MESA

La Alianza Científica para la Erradicación de la Malaria (MESA) tiene como objetivo avanzar en la ciencia de la erradicación de la malaria.

GenMoz

P. falciparum genomic intelligence in Mozambique

SMART

Identifying Severe Malaria with a new Aptamer-based Rapid diagnostic Test

CaDMIA-plus

Validación continuada de la autopsia mínimamente invasiva (MIA) para la investigación de la causa de muerte en niños pequeños, y desarrollo de un centro de investigación y formación sobre el estudio de la causa de muerte

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

MIBio

Identification of Prematurity and Pre-Eclampsia as Causes of Mortality

MA-CoV

Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations

IPERVAC-SL

Impact of perceptions of COVID-19 vaccines on health-seeking behaviours in Sierra Leone

RESPIRE

Respiratory syncytial virus (RSV) in African pregnant women and children

VITAL

Towards preparedness for new maternal vaccinations: Understanding barriers and facilitators to maternal vaccine acceptance

HIV drug resistance (HIVDR)

Description of HIV drug resistance patterns and its association with the risk of HIV mother to child transmission among pregnant women from southern Mozambique

PROTECT

PReparing for Optimal Phase III/IV maTErnal Group B StreptococCal vaccine Trials in Africa